"A Laboratory History of Narcotics, Vol. 1 Amphetamines and Derivatives", by Jared Ledgard
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"A Laboratory History of Narcotics, Vol. 1 Amphetamines and Derivatives", by Jared Ledgard

A Laboratory History of Narcotics, Vol. 1 Amphetamines and Derivatives
PAPERBACK: 260 pages
AUTHOR: Jared Ledgard
ISBN NUMBER: 978-0615156941
PUBLISHER: Jared Ledgard, 2007

A Laboratory History of Narcotics Vol 1 is a revolutionary book that covers the pharmaceutical preparation of amphetamines and amphetamine derivatives. This latest book by Jared Ledgard has reached another plateau of detail, and excellence in the area of laboratory science. The book contains a huge collection of pharmaceutical processes, and is by far one of Jared's greatest works. A Laboratory History of Narcotics, vol. 1 will propel you into a virtual labyrinth of psychedelic chemistry. If you think you know something about amphetamines and derivatives, your wrong. A must have book for anyone's reference collection and beyond. The book is an excellent reference for researchers, students, enthusiasts, and just plain people with a curiosity to know. NOTE TO CUSTOMERS: This book has been renamed from the preparatory manual of narcotics, to A Laboratory History of Narcotics Vol 1.

A LABORATORY HISTORY OF NARCOTICS

VOLUME 1

AMPHETAMINES AND DERIVATIVES

A LABORATORY MANUAL

By: Jared B. Ledgard

Table of Contents

SECTION 1: INTRODUCTION Page 001
A quick lesson in chemistry Page 001
Part 1: Introduction to chemistry Page 001
1. Chemical bonding: Oxidation states Page 001
2. Ionic compounds and ionic bonds Page 002
3. Covalent compounds and covalent bonds Page 003
4. Understanding chemical structures and formulas Page 004
5. Chemical reactions Page 006
6. Language of chemistry Page 006
7. Conversion factors Page 007
SECTION 2: LABORATORY TUTORIAL Page 009
Part 2: Laboratory tutorial on techniques and procedures Page 009
8. Introduction Page 009
9. Lab safety Page 009
10. Laboratory equipment Page 010
11. Methods of heating Page 012
12. Methods of Cooling Page 014
13. Extraction Page 016
14. Salting Out Page 018
15. Recrystallization, product recovery, and filtration Page 018
16. Filtration Page 019
17. Washing liquids and solids Page 021
18. Drying agents and drying liquids Page 022
19. Distillation Page 023
20. Apparatus design and function Page 026
SECTION 3: REFERENCE GUIDE Page 031
Intermediates, Reagents, and Solvents used in section 3 Page 031
SECTION 4: AMPHETAMINES AND DERIVATIVES Page 074
Introduction Page 074
Notes Page 075
Synthetic reduction note: replacing lithium aluminum hydride Page 076
A: Tin and hydrochloric acid technique Page 076
B: Hydrogenation using nickel, palladium, or platinum with or
without charcoal carrier Page 077
C. Reduction of the nitro intermediates with sodium borohydride Page 078
0001. 2-Phenyl-3-aminobutane (freebase). 1-methyl-2-phenylpropylamine Page 078
Procedure A: Preparation of 2-phenyl-3-aminobutane Page 078
0001-02. 2-Phenyl-3-aminobutane sulfate Page 081
Procedure A: Preparation of 2-phenyl-3-aminobutane sulfate Page 081
0002. beta-Methylphenylethylamine hydrochloride.
2-phenylpropan-1-amine hydrochloride Page 082
Procedure A: Preparation of beta-methylphenylethylamine
Hydrochloride Page 082
0003. beta-Methyl-(o- and p-)methylphenylethylamine
hydrochloride (mixed product) Page 084
Procedure A: Preparation of beta-Methyl-(o- and p-)
methylphenylethylamine hydrochloride Page 084
0004. beta-Methyl-p-methoxy-phenethylamine hydrochloride Page 086
Procedure A: Preparation of beta-Methyl-p-methoxy-
phenethylamine hydrochloride Page 086
0005. N-methyl-omega-phenyl-tert-butylamine. N,2-dimethyl-1
-phenylpropan-2-amine; New Ice; Extravagance. Page 087
Procedure A: Preparation of N-methyl-omega-phenyl-tert-butylamine Page 088
Preparation of omega-phenyl-tert-butylamine Page 091
0006. b-o-Methoxyphenyl-n-propylamine hydrochloride. 2-
(2-methoxyphenyl)propan-1-amine hydrochloride Page 092
Procedure A: Preparation of b-o-Methoxyphenyl-n-propylamine
Hydrochloride Page 093
0006-02. b-o-Methoxyphenyl propylmethylamine hydrochloride.
1-methoxy-2-(1-methylbutyl)benzene hydrochloride Page 097
Procedure A: Preparation of b-o-Methoxyphenyl propylmethylamine
Hydrochloride Page 097
Intermediate-0007. Ephedrine. 2-(methylamino)-1-phenylpropan-1-ol Page 099
Procedure A: Preparation of ephedrine (DL and L forms) Page 099
Procedure B: Preparation of ephedrine (predominately the DL form) Page 102
Intermediate-0007-02. Extraction of L-ephedrine from Ma Huang herb Page 103
Intermediate-0007-03. Extraction of pseudoephedrine from store bought
pseudoephedrine tablets ("Sudafed" "Galpseud", "Novafed", "Rhinalair",
"Otrinol", "Sinufed", Symptom 2", "Afrinol", and other nasal
decongestants and/or bronchodilators) Page 104
Intermediate-0008. Methedrine. 1-Phenyl-2-methyl-amino-ethan-1-ol Page 106
Procedure A: Preparation of methedrine (DL and L forms) Page 106
0009. Methamphetamine hydrochloride. N-methyl-N-(1-methyl-2-
phenylethyl)amine hydrochloride; speed; ice; crank; Page 108
Procedure A: Preparation of methamphetamine hydrochloride Page 108
Procedure B: Preparation of methamphetamine hydrochloride
(direct process; iodine process) Page 110
Procedure C: Preparation of racemic-methamphetamine hydrochloride
(ICE) Page 111
Intermediate-0010. Safrole. 5-allyl-1,3-benzodioxole Page 113
Procedure A: Extraction of safrole from sassafras oil Page 113
Procedure B: Synthesis of safrole from catechol Page 114
Procedure C: Synthesis of safrole from eugenol Page 116
Intermediate-0011. Piperonylacetone. 3,4-methylenedioxyphenylacetone.
1-(1,3-benzodioxol-5-yl)acetone Page 118
Procedure A: Synthesis of piperonylacetone Page 119
Procedure B: Synthesis of piperonylacetone from black pepper Page 121
0012. MDA hydrochloride. 1-(1,3-benzodioxol-5-yl)propan-2-amine
hydrochloride Page 124
Procedure A: Preparation of MDA hydrochloride Page 125
Procedure B: Preparation of MDA hydrochloride directly from safrole Page 128
Procedure C: Preparation of MDA hydrochloride from bromosafrole
using pressure apparatus Page 129
Procedure D: Preparation of MDA hydrochloride from
piperonylacetone using aluminum amalgam Page 131
Procedure E: Preparation of MDA hydrochloride Page 132
Procedure F: Preparation of MDA hydrochloride from piperonal Page 133
0013. MDMA. Ecstasy. 3,4-Methylenedioxymethamphetamine
hydrochloride. 1-(1,3-benzodioxol-5-yl)propan-2-amine hydrochloride Page 135
Procedure A: Preparation of MDMA Page 135
Procedure B: Preparation of MDMA from piperonylacetone via
amalgated aluminum reduction Page 137
Procedure C: Preparation of MDMA Page 139
Procedure D: Preparation of MDMA directly from bromosafrole Page 140
0014. MDEA. Eve. N-ethyl-3,4-methylenedioxyphenylisopropylamine
hydrochloride. 5-(2-methylpentyl)-1,3-benzodioxole hydrochloride Page 141
Procedure A: Preparation of MDEA Page 142
Procedure B: Preparation of MDEA from piperonylacetone via
amalgated aluminum reduction Page 143
Procedure C: Preparation of MDEA Page 145
Procedure D: Preparation of MDEA directly from bromosafrole Page 146
0015. Amphetamine hydrochloride. 1-methyl-2-phenylethylamine
hydrochloride Page 147
Procedure A: Preparation of Amphetamine hydrochloride Page 148
Procedure B: Preparation of racemic-Amphetamine sulfate Page 150
Procedure C: Preparation of racemic-Amphetamine hydrochloride
from toluene Page 151
0016. CAT. Methcathinone. 2-methyl-1-phenylbutan-1-one hydrochloride Page 155
Procedure A: Preparation of CAT Page 156
Procedure B: Preparation of CAT using potassium permanganate Page 157
0017. LE-25. 2C-D. 2-(2,5-dimethoxy-4-methylphenyl)ethanamine
hydrochloride Page 159
Procedure A: Preparation of LE-25 Page 159
0018. DOM. STP. 2,5-dimethoxy-4-methylamphetamine hydrochloride.
1-(2,5-dimethoxy-4-methylphenyl)propan-2-amine Page 162
Procedure A: Preparation of DOM Page 163
Intermediate-0019. 3,4,5-TMB. 3,4,5-Trimethoxybenzaldehyde Page 164
Procedure A: Preparation of 3,4,5-Trimethoxybenzaldehyde from
para-cresol Page 165
Procedure B: Preparation of 3,4,5-Trimethoxybenzaldehyde from
vanilla extract (food grade) Page 167
Procedure C: Preparation of 3,4,5-Trimethoxybenzaldehyde from
Syringaldehyde Page 169
0020. MESCALINE. M-345. 3,4,5-trimethoxyphenethylamine
hydrochloride. 2-(3,4,5-trimethoxyphenyl)ethanamine hydrochloride Page 170
Procedure A: Preparation of MESCALINE Page 171
Procedure B: Extraction of MESCALINE from San Pedro or
peyote cactus Page 173
Procedure C: Preparation of MESCALINE (cyanide process) Page 174
0021. BOM. Beta-Methoxymescaline hydrochloride. 3,4,5-beta-
tetramethoxyphenethylamine hydrochloride. 2-methoxy-2-
(3,4,5-trimethoxyphenyl)ethanamine Page 177
Procedure A: Preparation of BOM Page 178
0022. MMDA. 3-Methoxy-4,5-methylenedioxyamphetamine hydrochloride.
1-(7-methoxy-1,3-benzodioxol-5-yl)propan-2-amine hydrochloride Page 179
Procedure A: Preparation of MMDA Page 180
Procedure B: Preparation of racemic-MMDA Page 183
0023. BOH. beta-Methoxy-3,4-methylenedioxyphenethylamine
hydrochloride. 2-(1,3-benzodioxol-5-yl)-2-methoxyethanamine Page 186
Procedure A: Preparation of BOH Page 186
Intermediate-0024. Piperonal. 1,3-benzodioxole-5-carbaldehyde Page 188
Procedure A: Preparation of piperonal from protocatechualdehyde
via vanillin Page 189
Intermediate-0025. Eugenol. 4-allyl-2-methoxyphenol Page 192
Procedure A: Extraction of eugenol from cloves Page 192
Intermediate-0026. Myristicin. 6-allyl-4-methoxy-1,3-benzodioxole Page 193
Procedure A: Preparation of myristicin from eugenol Page 193
Procedure B: Preparation of myristicin by isolation from nutmeg Page 196
0027. BDB. 2-Amino-1-(3,4-methylenedioxyphenyl)butane hydrochloride.
1-(1,3-benzodioxol-5-yl)butan-2-amine hydrochloride Page 198
Procedure A: Preparation of BDB Page 198
0028. EDEN. 2-Methylamino-1-(3,4-methylenedioxyphenyl)butane
hydrochloride. Methyl-J. N-[1-(1,3-benzodioxol-5-ylmethyl)propyl]-
N-methylamine; MBDB Page 201
Procedure A: Preparation of EDEN Page 202
0029. THIOMESCALINE. 3,4-dimethoxy-5-methylthiophenethylamine
hydrochloride monohydrate. 5-[2-(chloroamino)ethyl]-1,2-dimethoxy-3-
(methylthio)benzene hydrochloride monohydrate Page 203
Procedure A: Preparation of THIOMESCALINE Page 204
0030. TMA. 3,4,5-Trimethoxyamphetamine hydrochloride. 1-
(3,4,5-trimethoxyphenyl)propan-2-amine hydrochloride Page 207
Procedure A: Preparation of TMA Page 207
0031. THIOESCALINE. Thioethylmescaline. 3-Thiometaescaline.
4,5-Dimethoxy-3-ethylthiophenethylamine hydrochloride. 2-[3-
(ethylthio)-4,5-dimethoxyphenyl]ethanamine hydrochloride Page 209
Procedure A: Preparation of THIOESCALINE Page 210
0032. 3M. 3M-Amphetamine. 5-Methoxy-4-methyl-2-
methylthioamphetamine hydrochloride. 1-[5-methoxy-4-methyl-2-
(methylthio)phenyl]propan-2-amine hydrochloride Page 213
Procedure A: Preparation of 3M Page 213
0033. LOPHOPHINE. 3-Methoxy-4,5-methylenephenethylamine
hydrochloride. 2-(7-methoxy-1,3-benzodioxol-5-yl)ethanamine
hydrochloride Page 217
Procedure A: Preparation of LOPHOPHINE Page 217
0034. IAP. Indanylamphetamine hydrochloride. 1-
(2,3-dihydro-1H-inden-5-yl)propan-2-amine hydrochloride Page 219
Procedure A: Preparation of IAP Page 220
0035. Methyl MDA. 5-methyl-MDA. 1-(7-methyl-1,3-benzodioxol-5-yl)
propan-2-amine Page 223
Procedure A: Preparation of Methyl MDA Page 224
0036. TMA2. 2,4,5-Trimethoxyamphetamine hydrochloride. 1-
(2,4,5-trimethoxyphenyl)propan-2-amine hydrochloride Page 229
Procedure A: Preparation of TMA2 Page 229
0037. ChloroMescaline. 2-Chloromescaline hydrochloride and
2,6-Dichloromescaline hydrochloride (DCM). 2-(2-chloro-3,4,5-
trimethoxyphenyl)ethanamine hydrochloride and 2-(2,6-dichloro-3,4,5-
trimethoxyphenyl)ethanamine hydrochloride (DCM) Page 234
Procedure A: Preparation of chloromescaline hydrochlorides Page 235
0038. DMMDA. 2,5-Dimethoxy-3,4-methylenedioxyamphetamine
hydrochloride. 1-(4,7-dimethoxy-1,3-benzodioxol-5-yl)propan-2-amine
hydrochloride Page 238
Procedure A: Preparation of DMMDA Page 239
0039. NitroMeth. Para-Nitro-phenyl-isopropylmethyl amine
hydrochloride. N-methyl-N-[1-methyl-2-(4-nitrophenyl)ethyl]amine
hydrochloride Page 243
Procedure A: Preparation of nitrometh Page 244
0040. Chlorometh. Chlorinated Methamphetamine. para-Chloro-
phenylisopropyl methylamine hydrochloride. N-[2-(4-chlorophenyl)-
1-methylethyl]-N-methylamine hydrochloride Page 245
Procedure A: Preparation of chlorometh Page 246
0041. BromoMeth. Brominated Methamphetamine. para-Bromo-
phenylisopropyl methylamine hydrobromide. N-[2-(4-bromophenyl)-
1-methylethyl]-N-methylamine hydrobromide Page 248
Procedure A: Preparation of bromometh Page 249
Final Wrap-up Page 250
References Page 253


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